| 机种 | 模拟器核心 | ROM路径 | 文件后缀 |
| 2048 | 2048 | | |
| 3DO | lr-4do** | 3do | .iso .cue |
| AMIGA | amiberry*, puae, uae4arm | amiga | .zip .uae .adf .dms .fdi .ipf .hdf .hdz .m3u |
| AMSTRADCPC | cap32,crocods | amstradcpc | .dsk .cpc |
| ARCADE | AdvMame, fba4arm, fbneo, mame2003_plus, mame2010, mame2015 | arcade, mame | .zip |
| ATARI26000 | stella2014 | atari2600 | .a26 .bin .gz .rom .zip |
| ATARI5200(800) | atari800 | atari5200 | .7z .a52 .atr .bas .bin .car .dcm .xex .xfd .zip .atr.gz .xfd.gz |
| ATARI7800 | prosystem | atari7800 | .7z .a78 .bin .zip |
| ATARILYNX | handy, mednafen_lynx | atarilynx | .7z .lnx .zip |
| ATARIST | hatari | atarist | .st .stx .msa .img .rom .raw .ipf .ctr |
| ATOMISWAVE | flycast | atomiswave | .zip |
| BANDAI WONDERSWAN | mednafen_wswan | wonderswan | .7z .ws .zip |
| BANDAI WONDERSWAN COLOR | mednafen_wswan | wonderswancolor | .7z .wsc .zip |
| C16/Plus4 | vice_xplus4 | c16 | .crt .d64 .g64 .t64 .tap .x64 .zip .prg |
| C64 | vice_x64 | c64 | .crt .d64 .g64 .t64 .tap .x64 .zip .prg |
| C128 | vice_x128 | c128 | .crt .d64 .g64 .t64 .tap .x64 .zip .prg |
| CVIC20 | vice_xvic | vic20 | .crt .d64 .g64 .t64 .tap .x64 .zip .prg |
| CANNONBALL | cannonball | ports/cannonball | .game .88 |
| CAVESTORY | nxengine | ports/CaveStory | .exe |
| CHAILOVE | chailove | n/a | .chai .chailove |
| COLECO | bluemsx | coleco | .bin .col .rom .zip |
| DOOM | prboom | ports/doom | .wad .pwad .iwad |
| DOOM 2 | prboom | ports/doom2 | .wad .pwad .iwad |
| FLASHBACK | reminiscence | ports/reminiscence | .map .aba .seq lev |
| GAMEANDWATCH | gameandwatch | gameandwatch | .mgw |
| GME | gme | | |
| INTELLIVISION | freeintv | intellivision | .7z .bin .int .itv .rom .zip |
| MICROSOFT MSX | bluemsx | msx | .rom .mx1 .mx2 .col .dsk .m3u |
| Nec PC 8800 | lr-quasi88 | pc88 | .d88 .88d .cmt .t88 |
| NEC PC 9800 | nekop2, np2kai | pc98 | d88 .d98 .88d .98d .fdi .xdf .hdm .dup .2hd .tfd .hdi .thd .nhd .hdd .fdd .cmd .hdn .zip |
| NEC PCENGINE | mednafen_pce_fast, mednafen_supergrafx | pcengine | .7z .ccd .chd .cue .pce .zip |
| NEC PCFX | mednafen_pcfx | pcfx | .img .iso .ccd .cue |
| NEC SGFX | mednafen_pce_fast, mednafen_supergrafx | sgfx | .7z .ccd .chd .cue .pce .zip |
| NEC TG16 | mednafen_pce_fast, mednafen_supergrafx | tg16 | .7z .ccd .chd .cue .pce .zip |
| NEC TG16CD | mednafen_pce_fast, mednafen_supergrafx | tg16cd | .pce .cue .ccd .iso .img .bin .chd |
| NINTENDO FAMICOM | fceumm, nestopia, quicknes | famicom | .nes .fds .unf .unif |
| NINTENDO FDS | fceumm, nestopia, quicknes | fds | .7z .fds .nes .zip |
| NINTENDO GAMEBOY | gambatte, mgba, tgbdual, gearboy, sameboy | gb | .7z .gb .zip |
| NINTENDO GAME BOY ADVANCE | mgba, gpsp, vba_next, vbam | gba | .7z .gba .zip |
| NINTENDO GBC | gambatte, mgba, tgbdual, gearboy, sameboy | gbc | .7z .gbc .zip |
| NINTENDO N64 | m64p, mupen64plus, mupen64plus_next, parallel_n64 | n64 | .z64 .n64 .v64 |
| NINTENDO NDS | drastic* (needs to be installed by user) | nds | .nds .zip |
| NINTENDO NES | fceumm,nestopia | nes | .7z .fds .nes .zip |
| NINTENDO SNES | snes9x2002, snes9x2005, snes9x2005_plus, snes9x2010,snes9x | snes | .7z .bin .bs .fig .mgd .sfc .smc .swc .zip |
| NINTENDO SFC | snes9x2002, snes9x2005, snes9x2005_plus, snes9x2010,snes9x | sfc | .7z .bin .bs .fig .mgd .sfc .smc .swc .zip |
| NINTENDO VIRTUALBOY | mednafen_vb | virtualboy | .vb .vboy .bin |
| OPENBOR | openbor* | openbor | .pak |
| VIDEOPAC ODYSSEY 2 | o2em | videopac | .bin |
| PC | dosbox | pc | .com .sh .bat .exe .conf |
| PICO-8 | pico8 | pico-8 | .png .p8 |
| QUAKE | tyrquake | ports/quake | .pak |
| RICKDANGEROUS | xrick | ports/xrick | .zip |
| SEGA DREAMCAST | REICAST, flycast | dreamcast | .gdi .cue .cdi |
| SEGA GAMEGEAR | genesis_plus_gx | gamegear | .7z .bin .gg .sms .zip |
| SEGA GENESIS | genesis_plus_gx, picodrive | genesis | .7z .bin .gen .md .sg .smd .zip |
| SEGA NAOMI | flycast | naomi | .zip |
| SEGA MASTERSYSTEM | genesis_plus_gx, masterboy, picodrive | mastersystem | .7z .bin .sms .zip |
| SEGA MEGADRIVE | genesis_plus_gx, picodrive | megadrive | .7z .bin .gen .md .sg .smd .zip |
| SEGA 32X | picodrive | sega32x | .32x .7z .bin .md .smd .zip |
| SEGA SATURN** | yabasanshiro | saturn | .bin .cue .iso .chd .mdf |
| SEGACD | genesis_plus_gx, picodrive | segacd | .bin .chd .cue .iso |
| SEGA SG-1000 | genesis_plus_gx | sg-1000 | .7z .bin .sg .zip |
| SNK NEOCD | libneocd,fbneo | neocd | .cue .bin |
| SNK NEO-GEO | AdvMame, fba4arm, fbneo, mame2003_plus, mame2010, mame2015 | neogeo | .zip |
| SNK NGP | mednafen_ngp | ngp | .7z .ngp .zip |
| SNK NGPC | mednafen_ngp | ngpc | .7z .ngc .zip |
| SONY PSP | PPSSPPSDL*, ppsspp | psp | .cso .iso .pbp |
| SONY PSX | pcsx_rearmed | psx | .cue .cbn .chd .img .iso .m3u .mdf .pbp .toc .z .znx |
| SCUMMVM | scummvm | scummvm | .scummvm |
| UZEBOX | uzem | | .uze |
| VECTREX | vecx | vectrex | .7z .bin .gam .vec .zip |
| SHARP X68000 | px68k | x68000 | .dim, .m3u |
| ZX81 | 81 | zx81 | .p .tzx .t81 |
| ZXSPECTRUM | fuse | zxspectrum | .sna .szx .z80 .tap .tzx .gz .udi .mgt .img .trd .scl .dsk |
| CAPCOM | AdvMame, fba4arm, fbneo, mame2003_plus, mame2010, mame2015 | capcom | |
| CPS1 | fbneo | cps1 | |
| CPS2 | fbneo | cps2 | |
| CPS3 | AdvMame, fba4arm, fbneo, mame2003_plus, mame2010, mame2015 | cps3 | |
| GAMEGEAR HACKS | genesis_plus_gx | gamegearh | |
| GB HACKS | gambatte, mgba, tgbdual, gearboy, sameboy | gbh | |
| GBA HACKS | mgba, gpsp, vba_next, vbam | gbah | |
| GENESIS HACKS | genesis_plus_gx, picodrive | genh | |
| MEGADRIVE-JAPAN | genesis_plus_gx, picodrive | megadrive-japan | |
| NES HACKS | fceumm,nestopia | nesh | |
| SNES HACKS | fceumm,nestopia | snesh | |
